Hodgkin's cell lines: Characteristics and possible pathogenetic implications
- 1 April 1983
- journal article
- research article
- Published by Wiley in Hematological Oncology
- Vol. 1 (2), 139-147
- https://doi.org/10.1002/hon.2900010204
Abstract
In the last four years we established five long term cultures from tumor material of Hodgkin's disease. The in vitro cells have malignant characteristics and represent the in vivo H- and SR-cells. Common immunological, functional and morphological assays did not characterize the in vitro cells to be a known cell type of lymphoid, myeloid or monocytoid tissue. The in vitro Hodgkin cells are biologically active by producing factors involved in regulation and promotion of immunological response and granulopoiesis. The relevance of the findings for pathogenesis and clinical appearance of Hodgkin's disease is discussed.Keywords
This publication has 9 references indexed in Scilit:
- Evidence for the detection of the normal counterpart of hodgkin and sternberg‐reed cellsHematological Oncology, 1983
- Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cellsNature, 1982
- Immunohistological analysis of Hodgkin's and Sternberg-Reed cells: Detection of a new antigen and evidence for selective IgG uptake in the absence of B cell, T cell and histiocytic markersZeitschrift für Krebsforschung und Klinische Onkologie, 1981
- Hodgkin's disease: Establishment and characterization of four in vitro cell linesZeitschrift für Krebsforschung und Klinische Onkologie, 1981
- Hodgkin's disease: biology, treatment, prognosisBlood, 1981
- Two neoplastic cell lines with unique features derived from Hodgkin's diseaseInternational Journal of Cancer, 1980
- Increasing frequency of acute myeloid leukemia complicating Hodgkin's disease: A reviewCancer, 1980
- Second malignancies in Hodgkin's disease: a complication of certain forms of treatment.BMJ, 1980
- Establishment of peripheral lymphoid cell cultures from patients with hodgkin's disease depending on epstein-barr-virus-reactivity and cellular immunityBlut: Zeitschrift für die Gesamte Blutforschung, 1977