Platelet Reactivity in Depressed Patients Treated With Paroxetine

Abstract

IN COMMUNITY studies, major depression is a major cause of emotional dysfunction, absenteeism, diminished productivity, and self-reported physical impairment.^1-6 Moreover, several studies have revealed that patients with depressive symptoms are at increased risk for developing ischemic heart disease (IHD)^7-13 and cerebrovascular disease,¹⁴ although some recent reports differ.^15,16 Indeed, of patients with IHD, 16% to 23% exhibit symptoms of major depression,^17-20 with the presence of depression predictive of future cardiac complications^9,17,21 and diminishing survival time.^19,22,23