Progress and Problems in the Fight against AIDS
- 26 March 1998
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 338 (13), 906-908
- https://doi.org/10.1056/nejm199803263381310
Abstract
In this issue of the Journal, Palella et al. provide evidence of a massive decrease in morbidity and mortality related to human immunodeficiency virus (HIV) infection.1 Among 1255 study participants who had at least one CD4+ cell count of fewer than 100 cells per cubic millimeter before enrollment, deaths decreased by 75 percent (from 35.1 to 8.8 per 100 person-years) between early 1994 and mid-1997, and the incidence of AIDS-defining diseases decreased by 73 percent (from approximately 50 to 13.3 per 100 person-years). During this period, progressively more intense antiretroviral therapy was introduced into clinical practice. These improvements occurred not . . .Keywords
This publication has 7 references indexed in Scilit:
- Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus InfectionNew England Journal of Medicine, 1998
- CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART)The Lancet, 1998
- Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: prospective multicentre studyBMJ, 1997
- Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapyAIDS, 1997
- Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centresAIDS, 1997
- Impact of Combination Therapy for HIV Infection on Inpatient CensusNew England Journal of Medicine, 1997
- Decline in deaths from AIDS due to new antiretroviralsThe Lancet, 1997