Sarcoma-Specific Antigens: Detection by Complement Fixation With Serum From Sarcoma Patients

Abstract

Complement-fixation studies revealed a high incidence of antibodies to a common sarcoma-specific antigen prepared from tissue cultures derived from human liposarcomas, fibrosarcomas, and osteosarcomas in the serum of sarcoma patients and their close family members. The presence of a common antigen in human sarcomas and the distribution of antisarcoma antibodies support the hypothesis of an associated infectious agent in human osteosarcoma and expand these findings to include soft-tissue sarcomas.