SURVIVAL OF THE VIRUS OF POLIOMYELITIS IN THE ORAL AND NASAL SECRETION OF CONVALESCENTS
Open Access
- 1 August 1936
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 64 (2), 173-182
- https://doi.org/10.1084/jem.64.2.173
Abstract
The positive detection of the virus of poliomyelitis in the nasal secretions of 2 children, 16 and 13 days after the onset of the disease, is described. 7 animals which had been inoculated with other concentrates became ill with symptoms and temperature elevations suggestive of poliomyelitis, from 1 to 3 weeks following inoculation, but without definite paralysis. In 2 of these animals which were sacrificed, the histologic findings were compatible with the diagnosis of poliomyelitis but were not typical. Of the serums of the 5 remaining animals 4 failed to neutralize stock virus, whereas the serum of the fifth neutralized the virus on two different occasions. This serum was obtained from a monkey that had been inoculated with concentrated nasal secretions of a child 43 days after the onset of illness. It is suggested that the present quarantine period of 3 weeks is compatible with the available data. It is further suggested that the methods of procedure described may be useful in similar investigations.This publication has 3 references indexed in Scilit:
- THE DETECTION OF POLIOMYELITIS VIRUS IN SO CALLED ABORTIVE TYPES OF THE DISEASEThe Journal of Experimental Medicine, 1932
- CARRIAGE OF THE VIRUS OF POLIOMYELITIS, WITH SUBSEQUENT DEVELOPMENT OF THE INFECTIONThe Journal of Experimental Medicine, 1917
- NEUTRALIZATION OF THE VIRUS OF POLIOMYELITIS BY NASAL WASHINGSThe Journal of Experimental Medicine, 1917