Scanning electron microscopy of the subarachnoid space in the dog: Evidence for a non‐hematogenous origin of subarachnoid macrophages
- 1 October 1979
- journal article
- research article
- Published by Wiley in Journal of Anatomy
- Vol. 156 (2), 183-205
- https://doi.org/10.1002/aja.1001560203
Abstract
Injection of viable BCG into the subarachnoid space of immunized and non-immunized dogs produced a 10-fold increase in the populations of pial free cells. In immunized animals injected three days previously with BCG, stereoscopic SEM revealed that many pial cells had rounded up and were protruding into the subarachnoid space. With continued rounding these cells took on amoeboid characteristics, with shapes that suggested a capacity for cell movement. Internally, these pial cells possessed an increased volume of perinuclear cytoplasm and organelles. Reactive pial cells could be distinguished from macrophages of presumed hematogenous origin on the basis of their surface morphology. These findings suggested that pial cells had the ability to alter their normal structural and behavioral characteristics and to become macrophage-like under these conditions of secondary challenge by BCG.This publication has 25 references indexed in Scilit:
- Scanning electron microscopy of the subarachnoid space in the dog. IV. Subarachnoid macrophagesJournal of Comparative Neurology, 1976
- Scanning electron microscopy of the subarachnoid space in the dog. III. Cranial levelsJournal of Comparative Neurology, 1975
- Scanning electron microscopy of the subarachnoid space in the dog. II. Spinal nerve exitsJournal of Comparative Neurology, 1974
- Scanning electron microscopy of the subarachnoid space in the dog. I. Spinal cord levelsJournal of Comparative Neurology, 1974
- Autoradiographic Studies on Histogenesis of Brain Macrophages in the MouseJournal of Neuropathology and Experimental Neurology, 1972
- The fine structure of cellular layers and connective tissue space at spinal nerve root attachments in the ratJournal of Anatomy, 1972
- Red Cells Coated with Immunoglobulin G: Binding and Sphering by Mononuclear Cells in ManScience, 1967
- THE FINE STRUCTURE OF ELASTIC FIBERSThe Journal of cell biology, 1966
- ORIGIN OF BRAIN MACROPHAGES IN THE MOUSEJournal of Neuropathology and Experimental Neurology, 1963
- An Electron-Microscopic Study of Bacterial MeningitisArchives of Neurology, 1962