Psymberin, A Potent Sponge-Derived Cytotoxin from Psammocinia Distantly Related to the Pederin Family
- 13 May 2004
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (12), 1951-1954
- https://doi.org/10.1021/ol049503q
Abstract
Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development.Keywords
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