ALDOSTERONE AND CORTICOSTERONE SECRETION RATES IN RATS WITH EXPERIMENTAL RENAL HYPERTENSION

Abstract

In animals with one renal artery clip hypertension was associated with a highly significant increase in aldosterone but not corticosterone secretion rate. In unilaterally nephrectomized animals with a clip on the remaining renal artery, hypertension was not associated with a significant change in the secretion rates of aldooterone or corticosterone. Experiments designed to determine whether this difference in the groups was due to the fact that in the first group the "clipped" kidney was still in the circulation during blood collection while in the second it was not have yielded essentially negative results. It is concluded that the increase in aldosterone secretion in renal hypertension is related to the response of the untouched kidney to the clamping of the renal artery of the other kidney.