SEROEPIDEMIOLOGY OF HEPATITIS B VIRUS IN ISRAEL

Abstract

Sandier, S. G. (Blood Bank, Hadassah-Hebrew University Medical Center, P.O.B. 499, Jerusalem, Israel), N. Nath and Y. Biger. Seroepldemlology of hepatitis B virus in Israel. Results of a pilot study in Jerusalem. Am J Epidemiol 106:76–82, 1977. One thousand thirty-three native and immigrant Israells, divided into 10-year age groups, were tested for the hepatitis B surface antigen (HB₂Ag) and antibody (anti-HB₃). The prevalence of anti-HB₃ was 10.1%, Increasing with age from the first (6.3%) through the fifth decade (16.2%) and declining slightly in the sixth and seventh decades. The age-adjusted prevalence of anti-HB₃ was higher for native Arabs (20.8%) compared with native Jews (4.8%), and for immigrants from North Africa (33.3%), compared with immigrants from the Middle and Near East (20.1%) and Western (“Ashkenazi”) countries (8.5%). Acquisition of anti-HB₃ was not correlated with a past history of jaundice or of blood transfusion. Of the positive sera reactive for anti-HB₃ that were subtypable, 74% were anti-y and 26%, anti-d specific. The prevalence of HB₅Ag for the study population was 1.8%, resulting in a prevalence of hepatitis B virus (HBV) infection, past and present, of 11.9%. These findings indicate that, while HBV infection is prevalent in Jerusalem, the most common presentation is a non-icteric illness with an age distribution extending through early adulthood and not coinciding with the early childhood clustering characteristic of icteric hepatitis in the region. The serologic findings are consistent with other clinical and epidemiologic evidence that endemic hepatitis in Jerusalem is predominantly the result of infection by “non-B” viruses.