Malignant (fibrous) histiocytoma arising in association with a bone infarct in sickle-cell disease: Coincidence or cause-and-effect?

Abstract
A patient with homozygous-S sickle-cell disease complicated by malignant (fibrous) histiocytoma arising within a tibial medullary infarct is reported. This is the ninth reported case of human sarcoma associated with bone infarct and the first associated with sickle-cell disease. Evidence for a causal relationship is presented.