The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (benzphetamine)in vivoin the rat
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 12 (10), 617-625
- https://doi.org/10.3109/00498258209042040
Abstract
1. The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (benzphetamine) was studied in vivo in the rat. 2. Nine metabolites were obtained from urine after oral administration of benzphetamine to rats. The major metabolite, identified as 1-(p-hydroxyphenyl)-2-(N-benzylamino)propane, was formed by aromatic hydroxylation and N-demethylation. One of the minor metabolites was methamphetamine, formed by N-debenzylation. 3. Metabolites excreted in three days after administration of the drug amounted to about 40% of the dose.This publication has 4 references indexed in Scilit:
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