THE BEHAVIOURAL EFFECTS OF TESTOSTERONE UNDECANOATE IN ADULT MEN WITH KLINEFELTER'S SYNDROME: A CONTROLLED STUDY
- 1 May 1982
- journal article
- clinical trial
- Published by Wiley in Clinical Endocrinology
- Vol. 16 (5), 489-497
- https://doi.org/10.1111/j.1365-2265.1982.tb02763.x
Abstract
The behavioural effects of exogenous testosterone in men with marginally low circulating androgen levels were investigated. Four adult men with Klinefelter's syndrome, low normal testosterone levels and normal sexual activity and interest were given testosterone undecanoate (TU 160 mg daily by mouth; Organon International) and placebo using a double blind cross‐over design. A modest increase in sexual interest was observed during TU administration compared to placebo, though there were no effects on self‐reported mood or energy, or on erectile responsiveness in the laboratory. Increase in circulating hormone levels during TU administration was more marked for DHT than for testosterone. The possible implications of this are discussed.Keywords
This publication has 21 references indexed in Scilit:
- Klinefelter's syndrome: Sexual development and activityArchives of Sexual Behavior, 1979
- Effects of Androgen on Sexual Behavior in Hypogonadal MenJournal of Clinical Endocrinology & Metabolism, 1979
- Long‐Term Study of Oral Testosterone Undecanoate in Hypogonadal MalesInternational Journal of Andrology, 1978
- A radioimmunoassay for testosterone in various biological fluids without chromatographyThe Journal of Steroid Biochemistry and Molecular Biology, 1978
- TRANSPLACENTAL GRADIENTS OF SEX‐HORMONE‐BINDING GLOBULIN IN HUMAN AND SIMIAN PREGNANCYClinical Endocrinology, 1976
- Reported coital activity of men and levels of plasma testosteroneArchives of Sexual Behavior, 1973
- A radioimmunoassay of androstenedioneSteroids, 1973
- PLASMA TESTOSTERONE VALUES IN DIFFERENT FORMS OF TESTOSTERONE TREATMENTActa Endocrinologica, 1969
- Testosterone in Human PlasmaNew England Journal of Medicine, 1965
- An analysis of mood in neurotics.The Journal of Abnormal and Social Psychology, 1964