Endogenous hyperglycemia restores insulin release impaired by somatostatin analogue
- 1 April 1981
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Endocrinology and Metabolism
- Vol. 240 (4), E407-E413
- https://doi.org/10.1152/ajpendo.1981.240.4.e407
Abstract
These studies assessed the ability of des-Asn5-[D-Trp8-D-Ser13]-somatostatin (d-ATS-SS) to selectively inhibit insulin release and produce a hyperglycemia sufficient to compensate for the original impairment. d-ATS-SS at 0.017 micrograms/min inhibited basal insulin output (delta = -38 +/- 6%, P less than 0.005) and increased basal pancreatic glucagon output (delta - +21 +/- 6%, P less than 0.05, n = 5). d-ATS-SS at 0.17 micrograms/min markedly inhibited insulin output (delta = -84 +/- 4%, P less than 0.0005) and slightly inhibited glucagon output (delta = -14 +/- 6%, P less than 0.05, n = 5). d-ATS-SS at 0.055 micrograms/min decreased basal and stimulated insulin release but not basal nor stimulated glucagon release. By 3.5 of analogue infusion, plasma glucose had risen by 116 +/- 13 mg/dl, and base-line insulin levels and the insulin responses to both isoproterenol and arginine, but not glucose, increased toward control values. We conclude that d-ATS-SS produces selective insulinopenia resulting in hyperglycemia which in turn compensates for the original impairment. Thus, the hyperglycemia observed in other states of selective insulin deficiency (e.g., noninsulin-dependent diabetes mellitus) may compensate for defects in beta-cell function.This publication has 23 references indexed in Scilit:
- Potentiation of Insulin Secretory Responses by Plasma Glucose Levels in Man: Evidence That Hyperglycemia in Diabetes Compensates for Impaired Glucose Potentiation*Journal of Clinical Endocrinology & Metabolism, 1979
- Mechanisms of Impaired Acute Insulin Release in Adult Onset Diabetes: Studies with Isoproterenol and Secretin*Journal of Clinical Endocrinology & Metabolism, 1978
- Quantitative Determination of the Interaction Between Epinephrine and Various Insulin Releasers in ManDiabetes, 1978
- The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog.JCI Insight, 1976
- Relationships Between Fasting Plasma Glucose Levels and Insulin Secretion During Intravenous Glucose Tolerance TestsJournal of Clinical Endocrinology & Metabolism, 1976
- Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon.JCI Insight, 1975
- Effects of Glucagon on Lipolysis and Ketogenesis in Normal and Diabetic MenJCI Insight, 1974
- Use of Benzamidine as a Proteolytic Inhibitor in the Radioimmunoassay of Glucagon in PlasmaJournal of Clinical Endocrinology & Metabolism, 1972
- Studies of secretin-stimulated insulin responses in manJCI Insight, 1972
- Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in manJCI Insight, 1969