Distribution and Nature of the "Antigen" Responsible for Experimental Meningoencephalomyelitis in the Guinea Pig.

Abstract

A widespread inflammation of the entire central nervous system with perivascular demyelinization may be produced in about 60% of guinea pigs 2 weeks to 2 months following the single subcut. injn. of guinea pig, human, rabbit, or beef brain and heat-killed tubercle bacilli in a water-in-oil emulsion. Human optic nerve, which contains only white matter, is also effective, as are phosphatide-like fractions of human or beef brain prepared according to the method of Page (Chemistry of the Brain, Chas. C. Thomas, Springfield, p.54).