Protection of Rats against Adjuvant Arthritis by Bacterial Lipopolysaccharides
- 17 August 1962
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 137 (3529), 544-545
- https://doi.org/10.1126/science.137.3529.544
Abstract
Lipopolysaccharides from both gram-negative and gram-positive bacteria in incomplete adjuvant caused rats to become resistant to mycobacterial (complete) adjuvant arthritis. Lipopolysaccharides h protected rats when they were administered in adjuvant did not protect when administered in saline. Mycobacterial wax D in saline was protective, while in adjuvant it produced arthritis. The degree of stimulation of a common tissue reaction may determine whether the result is protection or disease.Keywords
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