Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2
Open Access
- 1 December 2000
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 275 (52), 41415-41423
- https://doi.org/10.1074/jbc.m006871200
Abstract
No abstract availableKeywords
This publication has 64 references indexed in Scilit:
- Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 ActivationJournal of Biological Chemistry, 2000
- TIMP-2 Is Required for Efficient Activation of proMMP-2 in VivoJournal of Biological Chemistry, 2000
- Potent and Selective Mechanism-Based Inhibition of GelatinasesJournal of the American Chemical Society, 2000
- Biophysical and Functional Characterization of Full-length, Recombinant Human Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Produced in Escherichia coliJournal of Biological Chemistry, 1999
- MMP-2 and TIMP-2 Expression Correlates with Poor Prognosis in Cervical Carcinoma—A Clinicopathologic Study Using Immunohistochemistry and mRNA in Situ HybridizationGynecologic Oncology, 1999
- Membrane-type matrix metalloproteinase-1(MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomasJournal of Hepatology, 1998
- Matrix MetalloproteinasesDrugs & Aging, 1997
- The recombinant catalytic domain of membrane‐type matrix metalloproteinase‐1 (MT1‐MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP‐2FEBS Letters, 1996
- The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic ActivationJournal of Biological Chemistry, 1996
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970