Radiation Protection of Mice with Bone Marrow and Spleen Preserved at Low Temperature Using Polyvinylpyrrolidone

Abstract

The previously reported results^11-13 of low-temperature preservation of bone marrow with 10 per cent polyvinylpyrrolidone were re-evaluated on the radiation protection basis. The lethally irradiated mice show 80 per cent recovery after the transplanation of PVP-preserved isologous bone marrow, when compared to the recovery rate of the mice receiving fresh marrow. Slightly higher recovery resulted from the marrow preserved with glycerol. The spleen cells preserved with PVP also induce high recovery in irradiated mice.