Phenyl isocyanate protein compounds and their immunological properties

Abstract

The phenylureido-derivative of horse serum-globulin, injected.into rabbits, produced antibodies which gave precipitin reactions with the phenylureido-and p-bromophenylureido-cqmpounds of horse serum, chicken serum or even rabbit serum proteins, and with similar compounds of caseinogen and gelatin. The anti-sera to phenylureido-serum-globulin did not react very strongly with the unchanged globulin. The precipitin reaction between phenylureido-proteins and the anti-sera to these compounds was specifically inhibited by phenylureido-amino acid compounds of glycine, alanine, and lysine. The inhibition was complete with the lysine compound.