Carboplatin-induced gene expression changes in vitroare prognostic of survival in epithelial ovarian cancer
Open Access
- 28 November 2008
- journal article
- Published by Springer Nature in BMC Medical Genomics
- Vol. 1 (1), 59
- https://doi.org/10.1186/1755-8794-1-59
Abstract
We performed a time-course microarray experiment to define the transcriptional response to carboplatin in vitro, and to correlate this with clinical outcome in epithelial ovarian cancer (EOC). RNA was isolated from carboplatin and control-treated 36M2 ovarian cancer cells at several time points, followed by oligonucleotide microarray hybridization. Carboplatin induced changes in gene expression were assessed at the single gene as well as at the pathway level. Clinical validation was performed in publicly available microarray datasets using disease free and overall survival endpoints.Keywords
This publication has 40 references indexed in Scilit:
- Synergy between PPARγ Ligands and Platinum-Based Drugs in CancerCancer Cell, 2007
- Cancer Statistics, 2007CA: A Cancer Journal for Clinicians, 2007
- Oncogenic pathway signatures in human cancers as a guide to targeted therapiesNature, 2005
- Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesProceedings of the National Academy of Sciences, 2005
- Gene Expression Signature With Independent Prognostic Significance in Epithelial Ovarian CancerJournal of Clinical Oncology, 2004
- Semi-Supervised Methods to Predict Patient Survival from Gene Expression DataPLoS Biology, 2004
- Antisense strategies targeting protein kinase C: preclinical and clinical developmentSeminars in Oncology, 2003
- Exploration, normalization, and summaries of high density oligonucleotide array probe level dataBiostatistics, 2003
- From patterns to pathways: gene expression data analysis comes of ageNature Genetics, 2002
- Cisatracurium, but not mivacurium, induces apoptosis in human umbilical vein endothelial cells in vitroEuropean Journal of Anaesthesiology, 1999