Actions of levodopa on the blood pressure of conscious rabbits

Abstract

1 . In conscious rabbits, the rapid intravenous injection of levodopa alone does not have any significant effects on the blood pressure in doses up to 10 mg/kg. 2 . After inhibition of monoamine oxidase, levodopa induces a sustained pressor response. 3 . This response can be blocked by inhibition of extracerebral decarboxylase. 4 . Possible mechanisms for these interactions are discussed, together with their therapeutic implications in Parkinsonism.