Relative bioavailability of oral low dose methotrexate

Abstract

In 39 patients the bioavailability of methotrexate from the two tablets Emthexat 2.5 mg and Methotrexate 2.5 mg was assessed in a double-blind study after a single oral dose of 30 mg/m² Methotrexate. There was a considerable inter-individual variation of the serum pharmacokinetics in regard to C_max and t_max, independent on the MTX formulation. Emthexat 2.5 mg tablets and Methotrexate 2.5 mg tablets were bioequivalent according to the definition (AUC_E≥AUC_M×80%).