Viral Evolution during Structured Treatment Interruptions in Chronically Human Immunodeficiency Virus-Infected Individuals
Open Access
- 1 December 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (23), 12344-12348
- https://doi.org/10.1128/jvi.76.23.12344-12348.2002
Abstract
We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.Keywords
This publication has 20 references indexed in Scilit:
- Viral Dynamics during Structured Treatment Interruptions of Chronic Human Immunodeficiency Virus Type 1 InfectionJournal of Virology, 2002
- Preferential suppression of CXCR4-specific strains of HIV-1 by antiviral therapyJCI Insight, 2001
- Human Immunodeficiency Virus Type 1 Quasi Species That Rebound after Discontinuation of Highly Active Antiretroviral Therapy Are Similar to the Viral Quasi Species Present before Initiation of TherapyThe Journal of Infectious Diseases, 2001
- Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapyJCI Insight, 2000
- Enhancement of Human Immunodeficiency Virus Type 1–Specific CD4 and CD8 T Cell Responses in Chronically Infected Persons after Temporary Treatment InterruptionThe Journal of Infectious Diseases, 2000
- Some statistical methods for phylogenetic trees with application to HIV diseaseMathematical and Computer Modelling, 2000
- Rate of HIV-1 RNA rebound upon stopping antiretroviral therapyAIDS, 1999
- Quantifying Residual HIV-1 Replication in Patients Receiving Combination Antiretroviral TherapyNew England Journal of Medicine, 1999
- HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatmentAIDS, 1999
- Accuracy of estimated phylogenetic trees from molecular dataJournal of Molecular Evolution, 1983