RETINAL DEGENERATION IN THE MOUSE

Abstract

The mutant retinal degeneration, rd, is linked to wv in linkage group XVII with recombination of 13.4[plus or minus] 1.7%. Recombination between rd and low glucuronidase, g, another locus in this linkage group, is 15.4[plus or minus] 2.3% in males. This estimate is significantly different from tha found for rd and g in females by Paigen and Noell (5.1[plus or minus] 2.9%). The order of these 3 loci and luxate, 1x, is 1x, Wv, rd, g. The very similar mutant rodless retina, r, was shown by Keeler not to be closely linked to the W locus, r. and rd are therefore probably not alleles. A diligent search for r, long thought to be extinct, might uncover its presence among the many stocks of different origin known to be lacking retinal photoreceptor cells.