Two components of long-term potentiation induced by different patterns of afferent activation
- 1 October 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 347 (6292), 477-479
- https://doi.org/10.1038/347477a0
Abstract
Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.Keywords
This publication has 25 references indexed in Scilit:
- Optical imaging of calcium accumulation in hippocampal pyramidal cells during synaptic activationNature, 1989
- Long-term potentiation and NMDA receptors in rat visual cortexNature, 1987
- Differential effects of calcium entry blockers on pre- and postsynaptic influx of calcium in the rat hippocampus in vitroBrain Research, 1987
- Long-Term PotentiationAnnual Review of Neuroscience, 1987
- Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonistsNeuroscience Letters, 1986
- Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5Nature, 1986
- A functional correlate for the dihydropyridine binding site in rat brainNature, 1985
- Long-term potentiation as a candidate mnemonic deviceBrain Research Reviews, 1984
- Magnesium gates glutamate-activated channels in mouse central neuronesNature, 1984
- New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structuresBiochemistry, 1980