Treatment of Murine Cryptococcosis with Liposome-Associated Amphotericin B
- 1 May 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 145 (5), 748-752
- https://doi.org/10.1093/infdis/145.2.748
Abstract
Liposomes were prepared to incorporate large amounts of amphotericin B. BALB/c mice were challenged with Cryptococcus neoformans and given liposome-associated amphotericin B (AMBL) or amphotericin B-deoxycholate (AMBD) intravenously. Mice that were treated with AMBL survived longer and had lower tissue counts of cryptococci than mice treated with AMBD or untreated control mice. The reduced acute toxicity of AMBL permitted much larger doses of amphotericin B to be given than were possible with AMBD. AMBL is a novel vehicle of administration that reduces toxicity and concentrates the drug in the appropriate target organs.Keywords
This publication has 2 references indexed in Scilit:
- A comparison of negatively and positively charged liposomes containing entrapped polynosinic · polycytidylic acid for interferon induction in miceBiochimica et Biophysica Acta (BBA) - General Subjects, 1976
- Prognostic Factors in Cryptococcal MeningitisAnnals of Internal Medicine, 1974