Dose Dependence of Insulin-activated Gastric Acid Secretion in Patients with Duodenal Ulcer before and after Vagotomy

Abstract

The purpose has been to find the optimum dose of insulin to produce the maximal gastric acid response in patients with duodenal ulcer, before and after truncal vagotomy and pyloroplasty. Doses from 0.1 to 0.4 I. U. of insulin / kg body weight were used and the optimum dose was considered to be 0.2 I. U./kg b. w. intravenously, both pre- and postoperatively. Changes in the dosage of insulin resulted in small and most often insignificant differences in acid secretion, while significant differences in blood sugar always occurred.