Antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III)
- 1 April 1986
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 111 (2), 166-168
- https://doi.org/10.1007/bf00400758
Abstract
The antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III) against the P388 leukemia and against the B16 melanoma was investigated. The test compound showed high activity against these tumor models. The tumor inhibiting effect was in the range or better than the effects of the compounds cyclophosphamide, cisplatin, or 5-fluorouracil, which were tested as positive controls. The effective substance is a new, water soluble, anionic, nitrogen-heterocyclic coordinated, ruthenium species, exhibiting antitumor activity.Keywords
This publication has 4 references indexed in Scilit:
- Antitumor activity of phenyl substituted dihalogenobis (1-phenyl-1,3-butanedionato)titanium (IV) compounds.1985
- Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato) titanium(IV) compounds against Walker 256 carcinosarcoma. A new class of antineoplastic agents.1982
- Cis-Diamino-Dichloro-Platin(II)Klinische Wochenschrift, 1979
- Platinum Compounds: a New Class of Potent Antitumour AgentsNature, 1969