Amino Acid Metabolism in Acute Renal Failure
- 1 September 1974
- journal article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 180 (3), 350-355
- https://doi.org/10.1097/00000658-197409000-00016
Abstract
A solution of 8 essential I-amino acids and hypertonic dextrose was administered to 5 patients in acute postoperative renal failure in a program of hyperalimentation designed to decrease the patient's catabolic state and to accrue certain metabolic benefits. A sixth patient receiving intravenous glucose alone served as a control. The pretreatment plasma concentrations of amino acids in all 6 patients did not differ significantly from normal; following intravenous essential amino acids at a dose of approximately 12.6 gm/24 hours, no significant elevations out of the normal range of these substances occurred. Since urinary excretion rates did not dramatically increase, urinary loss was excluded as a possible cause for the failure of increase of plasma concentrations. The results suggest that the administration of an intravenous solution of 1-amino acids and hypertonic dextrose is associated with rapid clearance from the blood of these substances and, with a failure of increased urinary excretion, indirect evidence of amino acid utilization for protein synthesis has been obtained. Histidine supplementation in patients with acute renal failure is probably unnecessary based on the lack of significant decreases in histidine concentrations in these patients.Keywords
This publication has 14 references indexed in Scilit:
- Catheter Complications in Total Parenteral NutritionNew England Journal of Medicine, 1974
- Improved Survival from Acute Renal Failure after Treatment with Intravenous Essential L-Amino Acids and GlucoseNew England Journal of Medicine, 1973
- DiagnosisThe American Journal of Surgery, 1972
- INTRAVENOUS NUTRITION WITH AMINO ACID SOLUTIONS IN PATIENTS WITH CHRONIC URAEMIAJournal of Internal Medicine, 1972
- Treatment of acute renal failure with intravenous administration of essential amino acids and glucose.1972
- Treatment of Acute Renal Insufficiency After Aortoiliac SurgeryArchives of Surgery, 1971
- Acute Renal FailureArchives of Surgery, 1971
- Renal failure in surgical patients. Treatment with intravenous essential amino acids and hypertonic glucose.1970
- Treatment of Acute Renal Failure With Intravenous Essential L-Amino AcidsArchives of Surgery, 1969
- Pulmonary Embolism RevisitedAnnals of Surgery, 1969