Phenytoin Levels in Catamenial Epilepsy
- 1 April 1988
- Vol. 29 (2), 155-158
- https://doi.org/10.1111/j.1528-1157.1988.tb04412.x
Abstract
We studied the fluctuations in phenytoin (PHT) levels during ovulatory and menstrual phases of the cycle, in eight patients with catamenial epilepsy and in eight-age-matched controls. Pharmacokinetic studies of PHT were done in five patients with catamenial epilepsy. The difference in PHT levels during menstrual and ovulatory phase in catamenial group was 3.44 .+-. 3.25 .mu.g/ml as compared with 0.91 .+-. 2.03 .mu.g/ml in controls. The mean fall during menstrual phase was significant (p < 0.05) in the catamenial group. There was also rapid though statistically nonsignificant clearance of PHT during menses are compared with the ovulatory period. It is presumed that the fall in plasma PHT levels during menses, though still within therapeutic range, may be responsible for catamenial exacerbation of epilepsy.Keywords
This publication has 21 references indexed in Scilit:
- Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.Journal of Neurology, Neurosurgery & Psychiatry, 1986
- Treatment of seizures with medroxyprogesterone acetateNeurology, 1984
- Phenytoin pharmacokinetics in catamenial epilepsyNeurology, 1984
- Treatment of Menstrual Epilepsy with a Progesterone‐Only Oral ContraceptiveEpilepsia, 1977
- EPILEPTIC SEIZURES IN WOMEN RELATED to PLASMA ESTROGEN and PROGESTERONE DURING the MENSTRUAL CYCLEActa Neurologica Scandinavica, 1976
- Control of epilepsy with a single daily dose of phenytoin sodium.British Journal of Clinical Pharmacology, 1975
- The role of estrogens in catamenial exacerbation of epilepsyNeurology, 1959
- EPILEPSY AND MENSTRUATION: THE RÔLE OF WATER RETENTIONThe Lancet, 1956
- CATAMENIAL EPILEPSYThe Lancet, 1956
- Pitressin Diagnosis of Idiopathic EpilepsyBMJ, 1943