Trial of Different Intensities of Anticoagulation in Patients with Prosthetic Heart Valves
- 15 February 1990
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 322 (7), 428-432
- https://doi.org/10.1056/nejm199002153220703
Abstract
We compared the efficacy and complications of anticoagulation with warfarin in 258 patients with prosthetic heart valves treated with regimens of "moderate intensity" (prothrombin-time ratio, 1.5; international normalized ratio, 2.65) or "high intensity" (prothrombin-time ratio, 2.5; international normalized ratio, 9) in a prospective, randomized study. The two patient groups were followed up for 421 patient-years and 436 patient-years, respectively. Eleven patients were lost to follow-up.This publication has 16 references indexed in Scilit:
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