Sites of Action of Plant Growth Retardants on Cholesterol Biosynthesis by Cell-Free Rat Liver .Preparations

Abstract

Experiments with cell-free preparations of rat liver indicate that of the plant growth retardants Phosfon B, Phosfon D, B995, COlI, and Amo 1618 all but B995 inhibit at least one step between acetate and mevalonate in cholesterol biosynthesis. The results also demonstrate that all of the retardants, including B995, inhibit at least one step between mevalonate and cholesterol, and that several of them act at different points along this part of the biosynthetic sequence.