Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution
- 1 February 1985
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 313 (6004), 653-659
- https://doi.org/10.1038/313653a0
Abstract
Crystals of turkey skeletal muscle troponin-C reveal a molecule of 2 domains with an unusual structure. Two Ca2+ ions are bound to the C-terminal domain. The 2 cation-binding sites of the regulatory (N-terminal) domain are Ca2+ free; this domain adopts a markedly different conformation from the C-terminal domain. The 2 domains are connected by a long 9-turn .alpha.-helix; 3 of these turns are exposed fully to solvent.Keywords
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