Reaction pattern of mitochondrial antibodies of primary biliary cirrhosis (PBC) is species specific but not organ specific
- 1 June 1987
- journal article
- research article
- Published by Springer Nature in Journal of Bioenergetics and Biomembranes
- Vol. 19 (3), 239-253
- https://doi.org/10.1007/bf00762415
Abstract
The cross reactivity of a well-characterized PBC serum was studied with mitochondria from a number of sources. These studies were to establish the nonorgan, species specificity of the reaction of PBC sera. As well as confirming some previously reported data, we have strong evidence suggesting that, in spite of species differences inM r of the major antigenic bands, all mitochondria contain a set of common cross-reactive epitopes. The multiplicity of antigenic bands seen for mitochondria from some sources are shown to arise, in part, as proteolytically derived artefacts of bands of higherM r , retaining some antigenic reactivity.Keywords
This publication has 34 references indexed in Scilit:
- The PBC-specific antigenMolecular Aspects of Medicine, 1985
- Mitochondrial Antibodies in Primary Biliary Cirrhosis: Species and Nonspecies Specific Determinants of M2 AntigenHepatology, 1985
- ATPASE-ASSOCIATED ANTIGEN (M2): MARKER ANTIGEN FOR SEROLOGICAL DIAGNOSIS OF PRIMARY BILIARY CIRRHOSISThe Lancet, 1982
- SEROLOGICAL CLASSIFICATION OF CHRONIC CHOLESTATIC LIVER DISEASE BY THE USE OF TWO DIFFERENT TYPES OF ANTIMITOCHONDRIAL ANTIBODIESThe Lancet, 1980
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- Mitochondrial enzyme activities in liver biopsies from patients with alcoholic liver disease.Gut, 1978
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- Maturation of the head of bacteriophage T4Journal of Molecular Biology, 1973
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- NEW ANTIBODY IN EARLY SYPHILISThe Lancet, 1970