The terminal nucleotides of retrovirus DNA are required for integration but not virus production
- 31 October 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 306 (5939), 155-160
- https://doi.org/10.1038/306155a0
Abstract
Deletion of specific nucleotides at either end of the long terminal repeat of the avian retrovirus, spleen necrosis virus, results in replication-competent but integration-defective virus. This result supports 2 conclusions: the 5-base pair terminal inverted repeats and 3-7 adjacent nucleotides are required for integration; integration of retrovirus DNA is not required for retrovirus gene expression.This publication has 65 references indexed in Scilit:
- Molecular cloning and partial characterization of unintegrated linear DNA from gibbon ape leukemia virus.Proceedings of the National Academy of Sciences, 1981
- Nucleotide sequence analysis of the Long Terminal Repeat (LTR) of avian retroviruses: Structural similarities with transposable elementsCell, 1980
- Identification and characterization of dimeric and trimeric circular forms of avian sarcoma virus-specific DNAVirology, 1980
- A detailed model of reverse transcription and tests of crucial aspectsCell, 1979
- DNA of noninfectious and infectious integrated spleen necrosis virus (SNV) is colinear with unintegrated SNV DNA and not grossly abnormalCell, 1979
- Mapping unintegrated avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNACell, 1978
- Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sitesCell, 1978
- Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cellsJournal of Molecular Biology, 1978
- Sites of integration of infectious DNA of avian reticuloendotheliosis viruses in different avian cellular DNAsCell, 1978
- Covalently closed circular DNA of avian sarcoma virus: Purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresisJournal of Molecular Biology, 1976