URINARY EXCRETION OF OESTRONE, OESTRADIOL-17 , AND OESTRIOL AFTER INJECTION OF HYPERTONIC DEXTROSE INTO THE AMNIOTIC SAC

Abstract
Legal absortion was brought about by injecting 50% dextrose into the amniotic sac. Determination of oestrogens was done over 24 hr., in 8-hr. periods before and after injection. The duration of pregnancy of the cases studied varied from 15-20 weeks. A significant rise in the excretion of osetradiol-17[beta] and a significant decrease in the excretion of oestrone and oestriol was recorded. This is interpreted as being a result of altered placental metabolism of oestrogens during a period of asphyxia produced by dextrose which preceded the death of the foetus.