HEPATIC AND RENAL-FUNCTION IN RATS RECEIVING IMMUNOTHERAPEUTIC DOSES OF CYCLOSPORIN-A
- 1 January 1980
- journal article
- research article
- Vol. 61 (6), 631-634
Abstract
Adult Sprague-Dawley rats were given either 25 or 50 mg/kg cyclosporin A (Cy A) orally every 48 h during the course of an immune response to sheep red blood cells (SRBC). A profound reduction in serum hemagglutinin titers was observed at 7 and 14 days only in animals given 50 mg. Apart from a small transient elevation in transaminase levels, there were no serological indications of impaired hepatic or renal function at either Cy A dose. There was also no increase in urinary (N-acetyl-.beta.-D-glucosaminidase) levels, indicating the absence of renal tubular cell damage. These observations are consistent with the normal histological and ultrastructural findings in liver and kidney in this study.This publication has 20 references indexed in Scilit:
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