Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid
- 15 July 1982
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 206 (1), 165-168
- https://doi.org/10.1042/bj2060165
Abstract
Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by causing a substrate inhibition of tyrosine hydroxylase activity.Keywords
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