Linkage of Adhesion, Filamentous Growth, and Virulence in Candida albicans to a Single Gene, INT1

Abstract

Adhesion and the ability to form filaments are thought to contribute to the pathogenicity of Candida albicans, the leading cause of fungal disease in immunocompromised patients. Int1p is a C. albicans surface protein with limited similarity to vertebrate integrins. INT1 expression in Saccharomyces cerevisiae was sufficient to direct the adhesion of this normally nonadherent yeast to human epithelial cells. Furthermore, disruption ofINT1 in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice. Thus,INT1 links adhesion, filamentous growth, and pathogenicity in C. albicans and Int1p may be an attractive target for the development of antifungal therapies.