COMPARISON of five assays for immune complexes in the RHEUMATIC DISEASES. An Assessment of Their Validity for Rheumatoid Arthritis
Open Access
- 1 October 1982
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 25 (10), 1156-1166
- https://doi.org/10.1002/art.1780251003
Abstract
Clinical assessment (disease activity, severity, and extraarticular manifestations) of 101 rheumatoid arthritis patients was correlated with several laboratory tests, including 5 immune complex assays: the bovine conglutinin, 125I–C1q binding, monoclonal rheumatoid factor inhibition, Raji cell, and staphylococci binding assays. Elevated disease activity indices were most closely associated with the presence of immune complexes detected by the 125I–C1q and staphylococci binding assays. There were significant but weak correlations between the level of disease activity and the level of immune complexes as measured by the bovine conglutinin, 125I–C1q binding, Raji cell, and staphylococci binding assays. Articular disease severity, as measured by anatomic stage, was best discriminated by the bovine conglutinin, monoclonal rheumatoid factor inhibition, and staphylococci binding assays. Extraarticular manifestations were best discriminated by the Raji cell and staphylococci binding assays. We concluded that the sensitivity, specificity, predictive value, and overlap of the associations were not sufficient to warrant their wide use for the diagnosis and management of rheumatoid arthritis in individual patients. Conversely, the 125I–C1q and staphylococci binding assays were as good as the erythrocyte sedimentation rate and the IgG rheumatoid factor test (the 2 best tests of many examined) in assessing disease activity. Further prospective studies with these assays will determine their usefulness in following rheumatoid arthritis for a prolonged period.This publication has 47 references indexed in Scilit:
- Immune complexes in sjögren's syndromeArthritis & Rheumatism, 1980
- Circulating immune complexes in patients with necrotizing vasculitisClinical Immunology and Immunopathology, 1980
- Immune Complexes in Rheumatoid Arthritis Sera and Synovial FluidsArthritis & Rheumatism, 1979
- Comparison of Three Immunoassays for Immune Complexes in Rheumatoid ArthritisArthritis & Rheumatism, 1979
- Immune-Complex Assays: The State of the ArtNew England Journal of Medicine, 1978
- Immunodysplasia SymdromeJapanese Journal of Clinical Immunology, 1978
- Studies into the occurrence of soluble antigen‐antibody complexes in diseaseArthritis & Rheumatism, 1973
- Antinuclear factor in rheumatoid arthritis and related diseases.Annals Of The Rheumatic Diseases, 1967
- QUANTITATION OF THE ACTIVITY OF RHEUMATOID ARTHRITIS: 6. CORRELATION OF SYSTEMIC AND JOINT FINDINGSThe American Journal of the Medical Sciences, 1957