Inhibition of in vitro Heme Synthesis from N15-Glycine by 2-Ethyl-5-methylbenzimidazole.,

Abstract

2-Ethyl-5-methylbenzimidazole was found to be considerably more inhibitory than 2,5-dimethylbenzi-midazole, or benzimidazole, for the synthesis of heme by chicken erythrocytes incubated in vitro. The inhibitory activities were in the same relative order noted for multiplication of influenza A or B virus, and adds further support to the concept that the same basic mechanism, possibly involving a fundamental role of nucleic acid in biosynthesis, underlies both processes.