Effect of Chlorpropamide on Serum Glucose and Immunoreactive Insulin Concentrations in Patients with Maturity-onset Diabetes Mellitus
- 1 July 1967
- journal article
- research article
- Published by American Diabetes Association in Diabetes
- Vol. 16 (7), 487-492
- https://doi.org/10.2337/diab.16.7.487
Abstract
Serum glucose and immunoreactive insulin responses to an oral glucose load were measured before and several weeks after treatment with chlorpropamide in 18 patients with maturity-onset diabetes mellitus. The fall in serum glucose concentration produced by the sufonylurea compound was not associated with an increase in serum insulin concentration. Instead, there appeared to be a direct relationship between control of hyperglycemia and associated decreases in insulin concentration. These observations raised the possibility that sulfonylurea compounds may lower glucose concentration by means other than simply stimulating pancreatic insulin secretion.This publication has 7 references indexed in Scilit:
- Insulin-Regulatory Mechanisms and Diabetes MellitusNew England Journal of Medicine, 1963
- REDUCTION BY PHENFORMIN OF EXCESSIVE INSULIN LEVELS AFTER GLUCOSE LOADING IN OBESE AND DIABETIC SUBJECTS1963
- QUANTITATIVE EFFECTS OF GLUCOSE, SULFONYLUREAS, SALICYLATE, AND INDOLE-3-ACETIC ACID ON THE SECRETION OF INSULIN ACTIVITY INTO PANCREATIC VENOUS BLOOD*JCI Insight, 1962
- AN IMMUNOCHEMICAL ASSAY OF TOTAL EXTRACTABLE INSULIN IN MAN *JCI Insight, 1960
- The Potentiation of Exogenous Insulin by Tolbutamide in Depancreatized Dogs1JCI Insight, 1957
- LONG‐TERM STUDIES OF THE SULFONYLUREAS IN TOTALLY DEPANCREATIZED DOGSAnnals of the New York Academy of Sciences, 1957
- INSULIN-I131 METABOLISM IN HUMAN SUBJECTS: DEMONSTRATION OF INSULIN BINDING GLOBULIN IN THE CIRCULATION OF INSULIN TREATED SUBJECTS 1JCI Insight, 1956