The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF, from subarachnoid haemorrhage patients, on isolated tissues.
- 1 March 1983
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 46 (3), 214-220
- https://doi.org/10.1136/jnnp.46.3.214
Abstract
Peri-aneurysmal CSF was obtained at operation from 13 patients with subarachnoid hemorrhage from ruptured intracranial aneurysms. The 5-hydroxytryptamine antagonist ketanserin inhibited contractions of isolated human intracranial arteries, elicited by this CSF. The presence of 5-HT in CSF was confirmed by high performance liquid chromatography. The use of ketanserin in the therapy of postoperative cerebral vasospasm is discussed.This publication has 25 references indexed in Scilit:
- CSF serotonin concentrations and cerebral arterial spasm in patients with ruptured intracranial aneurysm.Stroke, 1982
- Individual variations in response of human cerebral arterioles to vasoactive substances, human plasma, and CSF from patients with aneurysmal SAHJournal of Neurosurgery, 1981
- Vasoconstrictor activity in cerebrospinal fluid from patients subjected to early surgery for ruptured intracranial aneurysmsJournal of Neurosurgery, 1981
- Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptorsLife Sciences, 1981
- Multiple Neurotransmitter ReceptorsJournal of Neurochemistry, 1980
- Relationship between presence of vasoconstrictor activity in cerebrospinal fluid and time after subarachnoid haemorrhage from rupture of cerebral arterial aneurysms.Journal of Neurology, Neurosurgery & Psychiatry, 1979
- An investigation with serial angiography into the evolution of cerebral arterial spasm following aneurysm surgeryJournal of Neurosurgery, 1978
- Cerebral Vasospasm with Ruptured Saccular Aneurysm — The Clinical ManifestationsNeurosurgery, 1977
- Experimental Study on the Genesis of Cerebral VasospasmStroke, 1975
- Surgical Risk as Related to Time of Intervention in the Repair of Intracranial AneurysmsJournal of Neurosurgery, 1968