Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
- 22 December 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 290 (5500), 2302-2303
- https://doi.org/10.1126/science.290.5500.2302
Abstract
Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.Keywords
This publication has 8 references indexed in Scilit:
- Family-Based Tests of Association in the Presence of LinkageAmerican Journal of Human Genetics, 2000
- A Unified Approach to Adjusting Association Tests for Population Admixture with Arbitrary Pedigree Structure and Arbitrary Missing Marker InformationHuman Heredity, 2000
- Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading EnzymeJournal of Neuroscience, 2000
- Replication of Linkage Studies of Complex Traits: An Examination of Variation in Location EstimatesAmerican Journal of Human Genetics, 1999
- A full genome scan for late onset Alzheimer's diseaseHuman Molecular Genetics, 1999
- Allele-Sharing Models: LOD Scores and Accurate Linkage TestsAmerican Journal of Human Genetics, 1997
- ApoE-4 and Age at Onset of Alzheimer's DiseaseNeurology, 1997
- Avoiding Recomputation in Linkage AnalysisHuman Heredity, 1994