Effect of heparin or fibrinogen depletion on lung fluid balance in sheep after emboli
- 1 July 1979
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 47 (1), 213-219
- https://doi.org/10.1152/jappl.1979.47.1.213
Abstract
Fibrinogen, fibrin, or their degradation products may be essential for the increased lung vascular permeability to fluid and protein that may occur after microemboli. Anesthetized ventilated sheep (20) lung nymph flow, pulmonary artery and left atrial pressures, thermodilution cardiac output and lymph/plasma protein concentrations were measured. Glass bead microemboli (200 .mu.m diameter) were injected to raise pulmonary vascular resistance to 3 times base-line values and cause increased lung lymph flow with a parallel increase in protein clearance, which is characteristic of increased lung vascular permeability. Neither large doses of heparin (3000 U[units]/kg) nor fibrinogen depletion with viper venom (ancrod, 2 U/kg), alone, affected steady-state pulmonary hemodynamics or lung fluid balance. These treatments prior to giving sufficient amounts of emboli to triple the pulmonary vascular resistance did not prevent the increased lung vascular permeability. Fibrin deposition on degradation is not essential to microembolic lung vascular injury in sheep.This publication has 4 references indexed in Scilit:
- Lung fluid exchange after uneven pulmonary artery obstruction in sheep.Circulation Research, 1978
- INTRAVASCULAR PLATELET-AGGREGATION AND ACUTE RESPIRATORY INSUFFICIENCY1977
- Intravascular coagulation associated with the adult respiratory distress syndromeAmerican Journal Of Medicine, 1976
- Humoral Transmission of Cardiorespiratory Changes in Experimental Lung EmbolismCirculation Research, 1964