Effect of a conjugate of daunomycin and antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells.
- 1 January 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (2), 621-625
- https://doi.org/10.1073/pnas.79.2.621
Abstract
Daunomycin was covalently attached via a dextran bridge to specific antibodies against rat .alpha.-fetoprotein produced in a horse. The effect of this conjugate on an .alpha.-fetoprotein-producing [rat] tumor was investigated in terms of cytotoxicity and inhibition or retardation of tumor development. The covalent conjugate was by both criteria more efficient than daunomycin alone or a mixture of daunomycin and specific antibodies or a conjugate of daunomycin with horse Ig. The conjugate may be useful as a specific cytotoxic agent against .alpha.-fetoprotein-producing tumors.This publication has 19 references indexed in Scilit:
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