Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice
- 2 February 2007
- journal article
- review article
- Published by Springer Nature in Cancer and Metastasis Reviews
- Vol. 26 (1), 5-14
- https://doi.org/10.1007/s10555-007-9039-1
Abstract
The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various anticancer agents. Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed. This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models.Keywords
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