Evaluation of bioavailability upon oral administration of cinnarizine-.BETA.-cyclodextrin inclusion complex to beagle dogs.

Abstract

The bioavailability of cinnarizine (CN) [an agent for increasing cerebral blood flow] upon oral administration of its .beta.-cyclodextrin complex to beagle dogs was investigated in comparison with that of CN alone. The dissolution rate at pH 3.0-6.8 was increased significantly by inclusion complexation, but there was not difference in the bioavailability of CN after oral administration of .beta.-cylodextrin complex and that of CN alone. The absorption of CN was decreased significantly when CN was administered with NaHCO3. No decrease was observed in the case of CN-.beta.-cylodextrin inclusion complex.