Cefamandole Therapy in Anaerobic Infections
Open Access
- 1 March 1979
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 15 (3), 337-341
- https://doi.org/10.1128/aac.15.3.337
Abstract
Thirty-one adult patients with infections due to anaerobic bacteria were treated with cefamandole. Bacteroides fragilis group (17) and Bacteroides melaninogenicus (13) were the most frequent anaerobes isolated. Duration of therapy varied from 2 to 49 days. Results were judged satisfactory in 26 cases, and unsatisfactory in 1 case. Four cases could not be evaluated. Adverse reactions occurred in 16 patients and included positive direct Coombs' test without hemolysis, transient liver function abnormalities, phlebitis, reversible neutropenia, fever, eosinophilia, and toxic epidermal necrolysis. The more significant reactions were associated with prolonged therapy. None was lethal. These data suggest that cefamandole is effective in treatment of most anaerobic infections.This publication has 12 references indexed in Scilit:
- Antibacterial Activity of Cefamandole III VitroThe Journal of Infectious Diseases, 1978
- Comparison of the Pharmacokinetics of Cefamandole and Other Cephalosporin CompoundsThe Journal of Infectious Diseases, 1978
- Cefamandole--A Review of Chemistry and MicrobiologyThe Journal of Infectious Diseases, 1978
- Cefamandole in Treatment of PeritonitisThe Journal of Infectious Diseases, 1978
- Observations in man on some pharmacologic features of cefamandoleClinical Pharmacology & Therapeutics, 1976
- Comparison of In Vitro Antimicrobial Activity of Cefamandole and Cefazolin with Cephalothin Against over 8,000 Clinical Bacterial IsolatesAntimicrobial Agents and Chemotherapy, 1976
- Activity of Cefamandole and Other Cephalosporins Against Aerobic and Anaerobic BacteriaAntimicrobial Agents and Chemotherapy, 1976
- Antibiotic susceptibility testing by a standardized single disk method.1966
- The Role of Suture Material on Tumor ImplantationJAMA, 1965
- Toxic epidermal necrolysis (Lyell)American Journal Of Medicine, 1964