Though xanthomatosis is but a single manifestation of a systemic pathologic condition, only recently has this disturbance in cholesterol metabolism seriously occupied the attention of any one but the dermatologists. Latterly the occurrence of cardiovascular involvement with cutaneous xanthomatosis has likewise been noted by the internists,1but because of the meagerness of the literature on the subject the impression is prevalent that this association is rare. To emphasize the fact that this is not an infrequent occurrence we are presenting 6 cases of xanthomatosis and coronary artery disease that we have seen during the past two years, illustrating their diagnostic features. REPORT OF CASES Case 1.— L. W., a man aged 32, first seen in June 1941, complained of substernal pain on exertion and after heavy meals. The family history revealed that his father had died of a heart attack at 48 and his mother of heart disease at