Combined effects of cold and somatostatin on glucose kinetics in dogs
- 1 June 1981
- journal article
- research article
- Published by Springer Nature in European Journal of Applied Physiology
- Vol. 46 (3), 249-259
- https://doi.org/10.1007/bf00423401
Abstract
The role of the endocrine pancreas in glucose production (Ra), utilization (Rd), and metabolic clearance (R'd) was investigated during acute exposure to cold in normal normothermic dogs. Two ambient temperatures (TaN=+25‡ C and TaC=−21‡ C) were selected. At TaC, metabolic rate and glucose turnover of the shivering dogs were 4.3 and 2.4 times, respectively, higher than in dogs resting at TaN. As compared with the pre-experimental period, somatostatin infusion at TaN induced a 25% (arterial) and 34% (portal) glucagon deficiency, while insulin concentration dropped by 59% (arterial) and 74% (portal). Similar values were obtained at TaC for glucagon (39% arterial and 47% portal) and for insulin (52% arterial and 56% portal). At TaN, these simultaneous hormonal alterations provoked a slight reduction in plasma glucose concentration which levelled down to 4.4 mM. This reduction was due to a decrease in Ra, followed by a parallel decrease in Rd whereas R'd remained unchanged. At TaC, plasma glucose concentration dropped to the same level but quickly rose again during somatostatin infusion. This rise was due to a larger reduction in Rd than in Ra, accompanied by an abrupt fall in R'd. This reduction in R'd appears to be an important mechanism able to restore euglycemia during global pancreatic hormone deficiency in cold exposed dogs.Keywords
This publication has 48 references indexed in Scilit:
- Influence of adrenalin on sugar transport in soleus, a red skeletal muscleMolecular and Cellular Endocrinology, 1978
- Factors controlling gastric-glucagon release.JCI Insight, 1977
- THE HYPOGLYCAEMIC ACTION OF SOMATOSTATIN IN THE ANAESTHETIZED DOGClinical Endocrinology, 1977
- Experimental Validation of Nonsteady Rate Measurements using a Tracer Infusion Method and Inulin as Tracer and TraceeCanadian Journal of Physiology and Pharmacology, 1974
- Somatostatin: Hypothalamic Inhibitor of the Endocrine PancreasScience, 1974
- EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTSThe Lancet, 1974
- Comparison of Carbohydrate Utilization in Running and Shivering DogsHormone and Metabolic Research, 1973
- Lactate Turnover and Oxidation in Normal and Adrenal-Demedullated Dogs during Cold ExposureCanadian Journal of Physiology and Pharmacology, 1971
- Rates of formation and oxidation of lactic acid in dogs at rest and during moderate exerciseCanadian Journal of Physiology and Pharmacology, 1969
- Chronic vascular cannulation in the dogCanadian Journal of Physiology and Pharmacology, 1969